<!DOCTYPE html>
<html class="client-nojs vector-feature-language-in-header-enabled vector-feature-language-in-main-page-header-disabled vector-feature-page-tools-pinned-disabled vector-feature-toc-pinned-clientpref-0 vector-toc-not-available vector-feature-main-menu-pinned-disabled vector-feature-limited-width-clientpref-1 vector-feature-limited-width-content-enabled vector-feature-custom-font-size-clientpref-1 vector-feature-appearance-pinned-clientpref-0 skin-theme-clientpref-day vector-sticky-header-enabled" lang="de" dir="ltr"><head>
<meta charset="UTF-8">
<title>Faktor-Xa-Inhibitor</title>
<meta name="viewport" content="width=device-width, initial-scale=1.0">
<link rel="icon" type="image/png" href="./_res_/favicon.png">
<link rel="canonical" href="https://de.wikipedia.org/wiki/Faktor-Xa-Inhibitor"> <link href="./_mw_/ext.cite.styles.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.wikimediamessages.styles.css" rel="stylesheet" type="text/css">
<link href="./_mw_/skins.vector.icons.css" rel="stylesheet" type="text/css">
<link href="./_mw_/skins.vector.search.codex.styles.css" rel="stylesheet" type="text/css">
<link href="./_mw_/skins.vector.styles.css" rel="stylesheet" type="text/css">
<meta name="ResourceLoaderDynamicStyles" content="">
<link href="./_mw_/ext.gadget.citeRef.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.gadget.defaultPlainlinks.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.gadget.dewikiCommonHide.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.gadget.dewikiCommonLayout.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.gadget.dewikiCommonStyle.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.gadget.dewikiDarkmode.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.gadget.dewikiResponsive.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.gadget.specialSearch.css" rel="stylesheet" type="text/css">
<link rel="stylesheet" type="text/css" href="./_mw_/site.styles.css">
<link rel="stylesheet" type="text/css" href="./_mw_/noscript.css">
<link rel="stylesheet" type="text/css" href="./_res_/footer.css">
<link rel="stylesheet" type="text/css" href="./_res_/vector-2022.css">
</head>
<body class="skin--responsive skin-vector skin-vector-search-vue mediawiki ltr sitedir-ltr mw-hide-empty-elt ns-0 ns-subject page-Faktor-Xa-Inhibitor rootpage-Faktor-Xa-Inhibitor skin-vector-2022 action-view">
<div class="mw-page-container">
<div class="mw-page-container-inner">
<div class="mw-content-container">
<main id="content" class="mw-body">
<header class="mw-body-header vector-page-titlebar">
<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Faktor-Xa-Inhibitor</span></h1>
</header>
<a id="top"></a>
<div id="bodyContent" class="vector-body ve-init-mw-desktopArticleTarget-targetContainer" aria-labelledby="firstHeading" data-mw-ve-target-container="">
<div id="contentSub">
<div id="mw-content-subtitle"></div>
</div>
<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr">
<p><b>Faktor-Xa-Inhibitor</b> (X <a href="R%C3%B6mische_Zahl" class="mw-redirect" title="Römische Zahl">römisch</a> <i>zehn</i>) beschreibt in einem Begriff den Wirkungsmechanismus der <a href="Wirkstoff" title="Wirkstoff">Wirkstoffe</a> aus der Klasse der <a href="Antikoagulation" title="Antikoagulation">Gerinnungshemmer</a>, deren Funktionsweise in einer <a href="Inhibitor" title="Inhibitor">Hemmung</a> des aktivierten <a href="Stuart-Prower-Faktor" title="Stuart-Prower-Faktor">Gerinnungsfaktors X</a>, eines zentralen Bestandteils der <a href="H%C3%A4mostase" title="Hämostase">Blutgerinnung</a>, besteht. Weitere gängige Bezeichnungen der Arzneistoffgruppe sind <i>Anti-Xa</i>, <i>Faktor-Xa-Hemmer</i>, <i>FXa-Inhibitoren</i> und – für die direkten Inhibitoren – <i>Xabane</i>.
</p>
<div class="mw-heading mw-heading2"><h2 id="Wirkstoffe">Wirkstoffe</h2></div>
<p>Direkte Inhibitoren:
</p>
<ul><li><a href="Apixaban" title="Apixaban">Apixaban</a> (Handelsname: Eliquis)</li>
<li>Betrixaban – in Europa nicht zur Behandlung zugelassen<sup id="cite_ref-Betrixaban_EMA_1-0" class="reference"><a href="#cite_note-Betrixaban_EMA-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></li>
<li><a href="Edoxaban" title="Edoxaban">Edoxaban</a> (Handelsname: Lixiana)</li>
<li>Otamixaban (Entwicklung 2013 eingestellt<sup id="cite_ref-pharmexec50_2-0" class="reference"><a href="#cite_note-pharmexec50-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup>)</li>
<li><a href="Rivaroxaban" title="Rivaroxaban">Rivaroxaban</a> (Handelsname: Xarelto)</li></ul>
<p>Indirekte Inhibitoren:
</p>
<ul><li><a href="Tinzaparin" title="Tinzaparin">Tinzaparin</a> (Handelsname: Innohep)</li>
<li><a href="Certoparin" title="Certoparin">Certoparin</a> (Handelsname: Mono-Embolex)</li>
<li><a href="Dalteparin" title="Dalteparin">Dalteparin</a> (Handelsname: Fragmin)</li>
<li><a href="Enoxaparin" class="mw-redirect" title="Enoxaparin">Enoxaparin</a> (Handelsname: Clexane)</li>
<li><a href="Fondaparinux" title="Fondaparinux">Fondaparinux</a> (Handelsname: Arixtra)</li>
<li><a href="Nadroparin" title="Nadroparin">Nadroparin</a> (Handelsname: Fraxiparin)</li>
<li>Reviparin (Handelsname: Clivarin, Clivarodi)</li></ul>
<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
<ol class="references">
<li id="cite_note-Betrixaban_EMA-1"><span class="mw-cite-backlink"><a href="#cite_ref-Betrixaban_EMA_1-0">↑</a></span> <span class="reference-text"><span class="cite"><a rel="nofollow" class="external text" href="https://www.ema.europa.eu/en/documents/smop-initial/questions-answers-refusal-marketing-authorisation-dexxience-betrixaban_en.pdf"><i>Refusal of the marketing authorisation for Dexxience (betrixaban).</i></a> <a href="Europ%C3%A4ische_Arzneimittel-Agentur" title="Europäische Arzneimittel-Agentur">EMA</a>, 27. Juli 2018,<span class="Abrufdatum"> abgerufen am 14. September 2020</span>.</span><span style="display: none;" class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2Fde.wikipedia.org%3AFaktor-Xa-Inhibitor&rft.title=Refusal+of+the+marketing+authorisation+for+Dexxience+%28betrixaban%29&rft.description=Refusal+of+the+marketing+authorisation+for+Dexxience+%28betrixaban%29&rft.identifier=https%3A%2F%2Fwww.ema.europa.eu%2Fen%2Fdocuments%2Fsmop-initial%2Fquestions-answers-refusal-marketing-authorisation-dexxience-betrixaban_en.pdf&rft.publisher=%5B%5BEurop%C3%A4ische+Arzneimittel-Agentur%7CEMA%5D%5D&rft.date=2018-07-27"> </span></span>
</li>
<li id="cite_note-pharmexec50-2"><span class="mw-cite-backlink"><a href="#cite_ref-pharmexec50_2-0">↑</a></span> <span class="reference-text"> <style data-mw-deduplicate="TemplateStyles:r261891140">
/* start https://de.wikipedia.org/ */
.mw-parser-output .webarchiv-memento a{color:inherit}
/* end https://de.wikipedia.org/ */
</style><a rel="nofollow" class="external text" href="https://web.archive.org/web/20131203005652/http://www.pharmatimes.com/article/13-09-02/More_details_on_failure_of_Sanofi_s_otamixaban_at_ESC.aspx">More details on failure of Sanofi's otamixaban at ESC</a> (<span class="webarchiv-memento"><a href="Webarchivierung#Begrifflichkeiten" title="Webarchivierung">Memento</a></span> vom 3. Dezember 2013 im <i><a href="Internet_Archive" title="Internet Archive">Internet Archive</a></i>), www.pharmatimes.com, abgerufen am 1. Dezember 2013</span>
</li>
</ol></div><!--htdig_noindex--><div><div class="zim-footer">
Dieser Artikel wurde von <a class="external text" title="Zuletzt bearbeitet am 2024-06-09" href="https://de.wikipedia.org/wiki/?title=Faktor-Xa-Inhibitor&oldid=245768078">Wikipedia</a> herausgegeben. Der Text ist unter <a class="external text" href="https://creativecommons.org/licenses/by-sa/4.0/deed.de">Creative Commons Attribution-Share Alike 4.0</a> verfügbar, sofern nicht anders angegeben. Für die Mediendateien können zusätzliche Bedingungen gelten.
</div>
</div><!--/htdig_noindex--></div>
</div>
</main>
</div>
</div>
</div>
<script src="./_webp_/webpHandler.js"></script>
</body></html>